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Immunohistochemistry (IHC) is a widely used technique for accurate identification and biological characterization of tissue types in neoplastic and non-neoplastic diseases. The Canadian Immunohistochemistry Quality Control (cIQc) was committed to systematically monitoring and improving the proficiency of IHC testing nationwide. The organization distributes IHC challenges to pathology laboratories, assesses participant staining and provides an anonymized summary of laboratory performance.